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KMID : 0377219990240020056
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Medical Journal of Chosun Univercity
1999 Volume.24 No. 2 p.56 ~ p.62
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Serum leptin level in type 2 diabetic patients
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Kim Hyun-Lee
Bae Hak-Yeon
Chang Sung-Jong
Kim Hee-Joong
Jung Jae-Yung
Kim Yang-Soo
Kim Tae-Goon
Park Yu-Hoan
Chung Choon-Hae
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Abstract
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Objective: Leptin, the product of obesity (ob) gene, is a 16-kDa peptide hormone secreted by adipocytes and is thought to be a homeostatic signal that contributes to body weight regulation through modulating feeding behavior and/or energy expenditure. Mutations of the ob gene that led to leptin deficiency or production of a truncated inactive protein are associated with hyperphagia, hypometabolism, obesity, and noninsulindependent diabetes mellitus(NIDDM) in obese ob/ob mice. Leptin’ s role in humans with obesity and NDDM is not known. Plasma leptin concentrations are shown to be elevated in obese humans. We questioned whether subjects with NIDDM have an altered regulation of serum leptin levels. Therefore, the object of this study is to evaluate the relationships between the serum leptin level and BMI, NIDDM.
Method: This study were made of 70 subjects(control: 35, NIDDM:35) at Chosun University Hospital in Kwangju from March, 1998 to September, 1998. We measured the height and weight for BMI. Also, we measured leptin and C-peptide through radioimmunoassay.
Result: The serum leptin concentration were not different in patients with type II diabetic and nondiabetic subjects (6.3 0.86/7.22 0.96, p=0.476) and the BMI was similar in diabetic and nondiabetic subjects(24 0.57/24 0.45, p=0.93). The leptin concentration were higher in women than in men regardless of diabetic status (diabetes: male 3.07 0.40 / female 8.20 1.18, p＜0.05 control: male 4.88 1.28 / female 8.60 1.25, p＜0.05).
Conclusion: We concluded that the leptin concentrations were not different in diabetic and nondiabetic subjects and that the association of leptin with sexual dimorphism was similar in diabetic and nondiabetic subjects.
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KEYWORD
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Leptin, Type 2 Diabetes Mellitus
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